Mycotoxins in broiler production

Authors

  • Helder Freitas de Oliveira Federal University of Goiás
  • Cristielle Nunes Souto Federal University of Goiás
  • Poliana Carneiro Martins Federal University of Goiás
  • Izabela Cruvinel Di Castro Federal University of Goiás
  • Alessandra Gimenez Mascarenhas Federal University of Goiás

DOI:

https://doi.org/10.5965/223811711722018292

Keywords:

aflatoxin, fumonisins, ochratoxins, trichothecenes, zearalenone

Abstract

The occurrence of mycotoxins has become a problem to be discussed, due to its harmfulness to humans and animal’s health, and may be an obstacle to the poultry economy. Mycotoxins are toxic metabolites produced by certain species of fungi and may contaminate food. Aflatoxins are mainly produced by Aspergillus flavus and Aspergillus parasiticus, and B1, B2, G1 and G2 are its best known types. Fumonisin, with its B1, B2 or B3 types, are produced by Fusarium, while ochratoxin A is produced by Penicillium and Aspergillus. The main trichothecenes mycotoxins are T-2 toxin, deoxynivalenol and diacetoxyscirpenol. Zearalenone, produced by different species of Fusarium fungi affects chickens only when they are exposed to extremely high levels of contamination. Generally, immunosuppression, hepatotoxicity and nephrotoxicity as a decrease in performance and production gains are the most observed effects. There are several laboratory methods that can be used for the determination of mycotoxins. In order to control the contamination, it is necessary to adopt proper farming practices which prevent fungi growth. Once grains and feed are contaminated, biological, physical and/or chemical decontamination methods may be employed, although the physical process with adsorbents mixed to the feed is more widely used. Due to the importance of mycotoxins to poultry production, it is necessary to adopt measures to prevent contamination, and also develop a control and an anti-fungal growth and toxin production program by reviewing the critical points favorable to the emergence of toxin-producing fungi.

Downloads

Download data is not yet available.

Author Biographies

Helder Freitas de Oliveira, Federal University of Goiás

Doctorate Student of Zootechnics, Department of Animal Production, Federal University of Goiás.

Cristielle Nunes Souto, Federal University of Goiás

Doctorate Student of Zootechnics, Department of Animal Production, Federal University of Goiás.

Poliana Carneiro Martins, Federal University of Goiás

Doctorate Student of Zootechnics, Department of Animal Production, Federal University of Goiás.

Izabela Cruvinel Di Castro, Federal University of Goiás

Master in Zootechnics, Department of Animal Production, Federal University of Goiás.

Alessandra Gimenez Mascarenhas, Federal University of Goiás

D.Sc. Associate Professor IV, School of Veterinary and Zootechnics, Department of Animal Production, Federal University of Goiás.

References

ABPA. 2015. Associação Brasileira de Proteína Animal. Relatório Anual de Atividades. Available at: http://abpa-br.com.br/files/RelatorioAnual_UBABEF_2015_DIGITAL.pdf. Accessed on: Jul. 29, 2017.

AMARAL KAS & MACHINSKI JUNIOR M. 2006. Métodos analíticos para determinação de aflatoxinas em milho e seus derivados: uma revisão. Revista Analytica 24: 56-58.

ANTONISSEN G et al. 2014. The mycotoxin deoxynivalenol predisposes for the development of clostridium perfringens-induced necrotic enteritis in broiler chickens. PLoS ONE 9: 1-8.

ARAVIND KL et al. 2003. Efficacy of esterified glucomannan to counteract mycotoxicosis in naturally contaminated feed on performance and serum biochemical and hematological parameters in broilers. Poultry Science 82: 571-576.

BACON CW et al. 2001. Biological control of Fusarium moniliforme in maize. Environment Health Perspectives 109: 325-332.

BATA Á & LÁSZTITY R. 1999. Detoxification of mycotoxin-contaminated food and feed by microorganisms. Trends in Food Science & Technology 10: 223-228.

BHAT RV & MILLER JD. 1991. Mycotoxins and food supply. Food, Nutrition and Agriculture 1: 27-31.

BOUHET S & OSWALD IP. 2005. The effects of mycotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune response. Veterinary Immunology and Immunopathology 108: 199-209.

BOUHET S et al. 2004. The mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. Toxicological Sciences 77: 165-171.

BROWN TP et al. 1992. Fumonisin mycotoxicosis in broilers: performance and pathology. Avian Diseases 36: 450-454.

BURDITT SJ et al. 1983. Survey of molds and mycotoxins for their ability to cause feed refusal in chickens. Poultry Science 62: 2187-2191.

CARÃO ACP et al. 2014. Métodos físicos e químicos de detoxificação de aflatoxinas e redução da contaminação fúngica na cadeia produtiva avícola. Ciência Rural 44: 699-705.

CHI MS et al. 1980. Effect of dietary zearalenone on growing broiler chicks. Poultry Science 59: 531-536.

CIGIĆ IK & PROSEN H. 2009. An overview of conventional and emerging analytical methods for the determination of mycotoxins. International Journal of Molecular Science 10: 62-115.

DÄNICKE S et al. 2007. On the interactions between Fusarium toxin-contamined wheat and nonstarch polysaccharide hydrolyzing enzymes in diets of broilers on performance, intestinal viscosity, and carryover of deoxynivalenol. Poultry Science 86: 291-298.

DAWSON RJ. 1991. A global view of the mycotoxin problem. In: International Conference Of The Fungi And Mycotoxins In Stored Products. Proceedings... Bangkok: ACIAR. p. 22-28 (ACIAR Proceedings, 36).

DILKIN P. 2002. Micotoxicose suína: aspectos preventivos, clínicos e patológicos. Biológico 64: 187-191.

DOERR JA et al. 1983. Effects of low levels chronic aflatoxicosis in broiler chickens. Poultry Science 62: 1971-1977.

DRASTIG K et al. 2016. Farm water productivity in broiler production: case studies in Brazil. Journal of Cleaner Production 135: 9-19.

DUVICK J. 2001. Prospects for reducing fumonisin contamination of maize through genetic modification Environmental Health Perspectives 109: 337-342.

EMAN. 2000. European Mycotoxin Awareness Network. Available at: http://mycotoxins.org. Access in: Jun, 15, 2015.

FERREIRA H et al. 2006. Aflatoxinas: um risco a saúde humana e animal. Revista Ambiência 2: 113-127.

FRISVAD JC & SAMSON RA. 1991. Filamentous fungi in foods and feeds: ecology, spoilage and mycotoxin production. In: ARORA DK et al. (Eds.) Handbook of applied mycology. New York: Marcel Dekker. p. 31-68.

FUJII S et al. 2004. Metodologia analítica imunoquímica com ênfase na detecção de micotoxinas - ficotoxinas no sistema agroalimentar. Alimentos e Nutrição 15: 273-284.

GARCIA AR et al. 2003. Evaluation of two mycotoxin binders to reduce toxicity of broiler diets containing ochratoxin A and T-2 toxin contamined grain. Avian Diseases 47: 691-699.

GERTNER LRS et al. 2008. Influência da fumonisina sobre a resposta imunológica de aves: revisão bibliográfica. Revista Acadêmica: Ciências Agrárias e Ambientais 6: 401-411.

GUPTA S et al. 2008. Individual and combined effects of ochratoxin A and Salmonella enterica serovar Gallinarum infection on pathological changes in broiler chickens. Avian Pathology 37: 265-272.

HARTMANN N et al. 2008. Quantification of zearalenone in various solid agroenvironmental samples using D6-Zearalenone as the internal standard. Journal of Agricultural and Food Chemistry 56: 2926-2932.

HOEHLER D & MARQUARDT RR. 1996. Influence of vitamins E and C on the toxic effects of ochratoxin A and T-2 toxin in chicks. Poultry Science 75: 1508-1515.

IAMANAKA BT et al. 2010. Micotoxinas em alimentos. Anais da Academia Pernambucana de Ciência Agronômica 7: 138-161.

KASUGA F et al. 1998. In vitro effect of deoxynivalenol on the differentiation of human colonic cell lines Caco-2 and T84. Mycopathologia 142: 161-167.

KIDD MT et al. 1995. Trichothecene mycotoxins depress the mononuclear-phagocytic system of young turkeys. Immunopharmacology and Immunotoxicology 17:385-398.

KIM EK et al. 2003. Hidden fumonisin in corn flakes. Food Additives & Contaminants 20: 161-169.

KUBENA LF et al. 1995. Influence of fumonisin B1, present in Fusarium moniliforme culture material, and T-2 toxin on turkey poults. Poultry Science 74: 306-313.

KUBENA LF et al. 2001. Cecal volatile fatty acids and broiler chick susceptibility to Salmonella typhimurium colonization as affected by aflatoxins an T-2 toxin. Poultry Science 80: 411-417.

LEE YW et al. 1985. The effect of a perified water-soluble fraction of a Fusarium roseum ‘Graminearum’ culture on reproduction of White Leghorn females. Poultry Science 64: 1077-1082.

LEINONEN I & KYRIAZAKIS I. 2016. How can we improve the environmental sustainability of poultry production? Proceedings of the Nutrition Society 75: 265-273.

LEUNG LW et al. 2003. Inhibitors of glycosphingolipid biosynthesis reduce transepithelial electrical resistance in MDCK I and FRT cells. American Journal of Physiology Cell Physiology 284: 1021-1030.

LEUNG MCK et al. 2006. Mycotoxins in pet food: a review on worldwide prevalence and preventative strategies. Journal of Agricultural and Food Chemistry 54: 9623-9635.

LINO CM et al. 2004. Fumonisinas: presença em alimentos, implicações na saúde e aspectos legislativos. Revista Portuguesa de Ciências Veterinárias 99: 181-192.

LOPES JM et al. 2006. Adição de bentonita sódica como adsorvente de aflatoxinas em rações de frangos de corte. Ciência Rural 36: 1594-1599.

LOPES PRS et al. 2009. Utilização de adsorvente em rações contendo aflatoxina para alevinos de jundiá. Revista Brasileira de Zootecnia 38: 589-595.

MARIANI GVC. 1998. Desempenho produtivo de frangos de corte submetidos à intoxicação experimental com aflatoxina em diferentes idades. Dissertação (Mestrado em Zootecnia). Santa Maria: UFSM. 79p.

MAZIERO MT & BERSOT LS. 2010. Micotoxinas em alimentos produzidos no Brasil. Revista Brasileira de Produtos Agroindustriais 12: 89-99.

MCLAUGHLIN J et al. 2004. Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms. American Journal of Physiology Cell Physiology 287: 1412-1417.

MIAZZO R et al. 2005. Efficacy of sodium bentonite as a detoxifier of broiler feed contaminated with aflatoxin and fumonisin. Poultry Science 84: 1-8.

MOSS MO & LONG MT. 2002. Fate of patulin in the presence of yeast Saccharomyces cerevisiae. Food Additives and Contaminants 19: 387-399.

NOGUEIRA S & OLIVEIRA MBPP. 2006. Prevalência de ocratoxina A em alimentos e consequentes problemas de segurança alimentar. Alimentação Humana 12: 69-75.

OGIDO R et al. 2004. Effects of prolonged administration of aflatoxins B1 and fumonisin B1 in laying Japanese quail. PoultryScience 83: 1953-1958.

OSWALD IP et al. 2003. Mycotoxin fumonisin B1 increases intestinal colonization by pathogenic Escherichia coli in pigs. Applied and Environmental Microbiology 69: 5870-5874.

PRELUSKY DB et al. 1996. Biological fate on fumonisin B1 in food-producing animals. Advances in Experimental Medicine and Biology 392: 265-278.

RODRIGUEZ-AMAYA DB & SABINO M. 2002. Pesquisa em micotoxinas no Brasil: a última década em foco. Brazilian Journal of Microbiology 33: 1-11.

ROSA CAR et al. 2001. Evaluation of the efficacy of bentonite from the south of Argentina to ameliorate the toxic effects of aflatoxin in broilers. Poultry Science 80: 139-144.

SANTURIO JM et al. 1999. Effect of sodium bentonite on the performance and blood variables of broiler chickens intoxicated with aflatoxins. British Poultry Science 40: 115-119.

SANTURIO JM. 2000. Micotoxinas e micotoxicoses na avicultura. Revista Brasileira de Ciência Avícola 2: 1-12.

SEEFELDER W et al. 2003. Bound fumonisin B1: analysis of fumonisin-B1 glyco and amino acid conjugates by liquid chromatography-electrospray ionization-tandem mass Spectrometry. Journal Agricultural and Food Chemistry 51: 5567-5573.

SEKIYAMA B et al. 2006. Processos de descontaminação de rações contendo micotoxinas. Revista Analytica 26: 64-67.

SENYUVA HZ et al. 2008. Determination of fumonisins B1 and B2 in corn by liquid chromatography/mass spectrometry with immunoaffinity column cleanup: single laboratory method validation. Journal of AOAC International 91: 598-606.

SMITH JW & HAMILTON PB. 1970. Aflatoxicosis in the broiler chicken. Poultry Science 49: 207-215.

SORIANO JM & DRAGACCI S. 2004. Intake, decontamination and legislation of fumonisins in foods. Food Research International 37: 367-374.

STREATFIELD SJ. 2006. Mucosal immunization using recombinant plant-based oral vaccines. Methods 38: 150-157.

TESSARI ENC et al. 2010. Effects of Aflatoxin B1 and Fumonisin B1 on Blood Biochemical Parameters in Broilers. Toxins 2: 453-460.

TESSARI ENC et al. 2005. Efeitos da aflatoxina B1 e fumonisina B1 sobre os níveis séricos de aspartato amino-transferase e proteína total de frangos de corte. Arquivos do Instituto Biológico72: 185-189.

YU Z et al. 2005. Anti-apoptotic action of zearalenone in MCF-7 cells. Ecotoxicology and Environmental Safety 62: 441-446.

ZHU Y et al. 2016. Innovative technologies for the mitigation of mycotoxins in animal feed and ingredients - A review of recent patents. Animal feed science and technology 216: 19-29.

ZINEDINE A et al. 2007. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food Chemichal Toxicology 45: 1-18.

Downloads

Published

2018-05-09

How to Cite

OLIVEIRA, Helder Freitas de; SOUTO, Cristielle Nunes; MARTINS, Poliana Carneiro; DI CASTRO, Izabela Cruvinel; MASCARENHAS, Alessandra Gimenez. Mycotoxins in broiler production. Revista de Ciências Agroveterinárias, Lages, v. 17, n. 2, p. 292–299, 2018. DOI: 10.5965/223811711722018292. Disponível em: https://periodicos.udesc.br/index.php/agroveterinaria/article/view/9019. Acesso em: 23 nov. 2024.

Issue

Section

Review Article - Science of Animals and Derived Products

Most read articles by the same author(s)