Extratos naturais como alternativa sustentável para o controle do Aedes aegypti: uma revisão atualizada

Autores

DOI:

https://doi.org/10.5965/223811712322024334

Palavras-chave:

Aedes aegypti, arbovírus, extratos naturais, controle vetorial, inseticida

Resumo

O Aedes aegypti é o principal vetor de vírus que causam doenças como dengue, febre amarela, Zika e Chikungunya, levando a altas taxas de morbidade e mortalidade em humanos e a custos substanciais de saúde. O método mais comum de controle do mosquito envolve o uso de inseticidas sintéticos; entretanto, o uso contínuo dessas substâncias leva à resistência das espécies e à contaminação ambiental. Em resposta a estes desafios, os extratos naturais surgiram como uma alternativa promissora para o controle de vetores, pois contêm componentes potencialmente tóxicos para os mosquitos. O objetivo desta revisão é apresentar o estado atual do uso de extratos naturais como estratégia de controle tanto larval quanto adulto de Ae. aegypti. Por meio da recuperação de informações em bases de dados, considerando artigos originais publicados de 2018 a 2023, buscamos informações relacionadas à parte da planta utilizada para obtenção do extrato, métodos de extração e solventes utilizados. Foram encontrados 676 artigos, dos quais 35 atenderam aos critérios estabelecidos. Nessas publicações foram identificadas 38 famílias, 69 gêneros e 87 espécies de plantas, com destaque especial para as famílias Asteraceae, Anacardiaceae, Myrtaceae e Lamiaceae devido ao maior número de espécies utilizadas em pesquisas. Por outro lado, os métodos mais utilizados para obtenção de extratos incluíram maceração com posterior filtração, bem como extração Soxhlet. Enquanto isso, os solventes preferidos para obtenção do extrato foram etanol e água. Concluindo, existe um uso generalizado de extratos de plantas como inseticidas, com potencial extraordinário para controlar populações de vetores como Ae. aegypti e, por sua vez, contribuir para a redução da transmissão de arbovírus por esse mosquito.

Downloads

Não há dados estatísticos.

Referências

AGUIRRE OA et al. 2018. Actividad larvicida de extractos vegetales de la familia Asteraceae y modelación matemática para su uso en el control de poblaciones de Aedes aegypti. Actualidades Biológicas 40: 5-16.

ALI SI & VENKATESALU V. 2020. Evaluation of the larvicidal potential of root & leaf extracts of Saussurea costus (Falc.) Lipsch. against three mosquito vectors: Anopheles stephensi, Aedes aegypti, & Culex quinquefasciatus. Revista da Sociedade Brasileira de Medicina Tropical 53.

ALYAHYA HS et al. 2021. Natural Extracts as Eco-Friendly Larvicides Against Aedes Aegypti Mosquito, Vector of Dengue Fever Virus in Jeddah Governorate. Biosciences Biotechnology Research Asia 14: 219-226.

AL-ZAHRANI MR et al. 2019. Bioefficacy of some insect growth regulators and plant extracts against mosquito larvae of Aedes aegypti. GSC Biological and Pharmaceutical Sciences 6: 1-6.

AMELIA ZH et al. 2018. Pyrethroid resistance in the dengue vector Aedes aegypti in Southeast Asia: current status and management prospects. Parasites & Vectors 11: 11-17.

ANOOPKUMAR AN & ANEESH EM. 2022. A critical assessment of mosquito control and the influence of climate change on mosquito-borne disease epidemics. Environment, Development and Sustainability 24: 8900-8929.

ARAÚJO IF et al. 2020. Larvicidal activity of the methanolic, hydroethanolic & hexanic extracts from Acmella oleracea, solubilized with silk fibroin, against Aedes aegypti. Biocatalysis & Agricultural Biotechnology 24: 101550.

BEKELE D. 2018. Review on insecticidal & repellent activity of plant products for malaria mosquito control. Biomedical 2: 2-7.

BOBADILLA MC & REYES SM. 2020. Efecto tóxico de los extractos de semillas de Annona muricata potenciados con dimetilsulfóxido sobre larvas IV y pupas de Aedes aegypti. Revista Peruana de Biología 27: 215-224.

BORGES JC et al. 2019. Mosquiticidal & repellent potential of formulations containing wood residue extracts of a Neotropical plant, Tabebuia heptaphylla. Industrial Crops & Products 129: 424-433.

BOSLY HAEK. 2022. Larvicidal and adulticidal activity of essential oils from plants of the Lamiaceae family against the West Nile virus vector, Culex pipiens (Diptera: Culicidae). Saudi Journal of Biological Sciences 29: 8-103350.

BRAACK L et al. 2018. Mosquito-borne arboviruses originating from Africa: A comprehensive review of key viruses and vectors. Parasites & Vectors 11: 1-26.

CARNEIRO VC et al. 2020. Larvicidal activity of plants from Myrtaceae against Aedes aegypti L. & Simulium pertinax Kollar (Diptera). Revista da Sociedade Brasileira de Medicina Tropical 54: e00922020.

CHELLAPPANDIAN M et al. 2019. Target & non-target botanical pesticides effect of Trichodesma indicum (Linn) R. Br. & their chemical derivatives against the dengue vector, Aedes aegypti L. Environmental science & pollution research 26: 16303-16315.

CRUZ AD et al. 2022. Larvicidal activity of the crude methanolic extract from leaves of Clibadium surinamense against Aedes aegypti. Ciência Rural 53: e20210786.

DE OLIVEIRA AA et al. 2021. Larvicidal, adulticidal & repellent activities against Aedes aegypti L. of two commonly used spices, Origanum vulgare L. & Thymus vulgaris L. South African Journal of Botany 140: 17-24.

DE SANTANA LL et al. 2019. Exposure of mosquito (Aedes aegypti) larvae to the water extract & lectin-rich fraction of Moringa oleifera seeds impairs their development & future fecundity. Ecotoxicology & Environmental Safety 183: 109-583.

FALKOWSKI M et al. 2020. Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana. Acta tropica 201: 105179.

FERNANDES DA et al. 2021. Ovicidal, pupicidal, adulticidal, & repellent activity of Helicteres velutina K. Schum against Aedes aegypti L. (Diptera: Culicidae). Brazilian Journal of Veterinary Medicine 43: e102120.

FERREIRA MD et al. 2019. Phytochemical study of Waltheria viscosissima & evaluation of its larvicidal activity against Aedes aegypti. Revista Brasileira de Farmacognosia 29: 582-590.

FLASCHE S et al. 2019. Estimating the proportion of vaccine induced hospitalized dengue cases among Dengvaxia vaccines in the Philippines. Wellcome Open Res 31:165.

GHOSH A et al. 2012. Plant extracts as potential mosquito larvicides. The Indian Journal of medical research 135: 581.

GRANADOS JA et al. 2021. Extracto de Acacia farnesiana para el control de larvas de Aedes aegypti. Nova Scientia 13: 27.

HARI I & MATHEW N. 2018. Larvicidal activity of selected plant extracts & their combination against the mosquito vectors Culex quinquefasciatus & Aedes aegypti. Environmental Science & Pollution Research 25: 9176-9185.

HIKAL WM et al. 2017. Botanical insecticide as simple extractives for pest control. Cogent Biology 3: 1404274.

KANIS LA et al. 2018. Piper ovatum (Piperaceae) extract/starch-cellulose films to control Aedes aegypti (Diptera: Culicidae) larvae. Industrial Crops & Products 122: 148-155.

LOUIS ML et al. 2020. Mosquito larvicidal activity of Avocado (Persea americana Mill.) unripe fruit peel methanolic extract against Aedes aegypti, Culex quinquefasciatus & Anopheles stephensi. South African Journal of Botany 133: 1-4.

LUZ TRSA et al. 2020. Essential oils and their chemical constituents against Aedes aegypti L. (Diptera: Culicidae) larvae. Acta Tropica 212: 105705.

MACEDO AL et al. 2018. Isolation of a larvicidal compound from Piper solmsianum (Piperaceae). Natural product research 32: 2701-2704.

MAHDI N et al. 2022. Bio-efficacy of Mangifera leaf extracts on mortality of Aedes aegypti and inhibition of egg hatching. Veterinary world, 15: 1753–1758.

MARTIANASARI R & HAMID PH. 2019. Larvicidal, adulticidal, and oviposition-deterrent activity of Piper betle L. essential oil to Aedes aegypti. Veterinary world 12: 3-367.

MARTINS MM et al. 2021. Larvicidal activity of Maytenus guianensis (Celastraceae) against Aedes aegypti (Diptera: Culicidae). Revista da Sociedade Brasileira de Medicina Tropical 54: e0835.

MITUIASSU LM et al. 2021. Momordica charantia L. extracts against Aedes aegypti larvae. Brazilian Journal of Biology 82: e236498.

MORAIS HL et al. 2020. Hydroalcoholic extract of Caryocar brasiliense Cambess leaves affect the development of Aedes aegypti mosquitoes. Revista da Sociedade Brasileira de Medicina Tropical 53: e20200176.

MUANGMOON R et al. 2018. Natural larvicides of botanical origin against dengue vector Aedes aegypti (Diptera: culicidae). Southeast Asian Journal of Tropical Medicine & Public Health 49: 227-239.

NELSON MJ. 1986. Aedes Aegypti: Biología y ecología. Washington: Organização Pan-Americana da Saúde. 62p.

NINDITYA V et al. 2020. Artemisia vulgaris efficacies against various stages of Aedes aegypti. Veterinary World 13: 1423.

OLIVEROS DA et al. 2022. Larvicidal activity of plant extracts from Colombian North Coast against Aedes aegypti L. mosquito larvae. Arabian Journal of Chemistry 15: 104365.

PAHO. 2023. PANAMERICAN HEALTH ORGANIZATION. Vacuna contra la fiebre amarilla.

PANDEY V et al. 2021. The Influence of Climate Change on the Occurrence of Vector-Borne Diseases. In Recent Technologies for Disaster Management and Risk Reduction: Sustainable Community Resilience & Responses 203-228.

PILAQUINGA F et al. 2019. Green synthesis of silver nanoparticles using Solanum mammosum L. (Solanaceae) fruit extract & their larvicidal activity against Aedes aegypti L (Diptera: Culicidae). PLoS One 14.

PINEDA CM et al. 2019. Larvicidal & ovicidal activities of Artocarpus blancoi extracts against Aedes aegypti. Pharmaceutical biology 57: 120-124.

PINTADO SILVA J & FERNANDEZ-SESMA A. 2023. Challenges on the development of a dengue vaccine: a comprehensive review of the state of the art. Journal of General Virology 104: 001831.

PORUSIA M & SEPTIYANA D. 2021. Larvicidal activity of Melaleuca leucadendra leaves extract against Aedes aegypti. Caspian Journal of Environmental Sciences 19: 277-285.

PRADA AR et al. 2021. Control de larvas de Aedes aegypti con extractos de Allium sativum y Annona muricata como larvicidas. Revista de Salud Pública 23: 1-8.

PRATHEEBA T et al. 2019. Antidengue potential of leaf extracts of Pavetta tomentosa & Tarenna asiatica (Rubiaceae) against dengue virus & its vector Aedes aegypti (Diptera: Culicidae). Heliyon 5: e02732.

QIE X et al. 2022. A potential lignan botanical insecticide from Phryma leptostachya against Aedes aegypti: laboratory selection, metabolic mechanism, and resistance risk assessment. Journal of Pest Science 95: 397-408.

RAJASHEKARA S et al. 2021. Screening of plant extracts against a vector of arboviruses, Aedes aegypti (Linnaeus) (Diptera: Culicidae). In Proceedings of the Zoological Society 74: 205-210.

REINHOLD J et al. 2018. Effects of the environmental temperature on Aedes aegypti and Aedes albopictus mosquitoes: a review. Insects 9: 158.

REZENDE P et al. 2022. What can we learn from commercial insecticides? Efficacy, toxicity, environmental impacts, and future developments. Environmental Pollution 300: 118983.

RODRIGUES AM et al. 2019. Different susceptibilities of Aedes aegypti & Aedes albopictus larvae to plant-derived products. Revista da Sociedade Brasileira de Medicina Tropical 52: e20180197.

SANTOS GV et al. 2022. Aedes aegypti queenslandensis: first geographic occurrence in Brazil & epidemiological implications. Revista Brasileira de Entomologia 66: e20210112.

SHAJAHAN A et al. 2022. A review on plant phytochemicals potential for mosquito control. International Journal of Mosquito Research 9: 47-54

SHARMA A et al. 2019. Evaluation of bioactivity of aqueous extracts of Bougainvillea spectabilis, Saraca asoca, & Chenopodium album against immature forms of Aedes aegypti. Medical journal armed forces India 75: 308-311.

SIGAMANI S et al. 2020. Larvicidal potency of the extracts from Chlorella sp. against Aedes aegypti. Biocatalysis & Agricultural Biotechnology 27: 101663.

SILVÉRIO MR et al. 2020. Plant natural products for the control of Aedes aegypti: The main vector of important arboviruses. Molecules 25: 3484.

SPINOZZI E et al. 2023. Carlina acaulis L. (Asteraceae): biology, phytochemistry, & application as a promising source of effective green insecticides & acaricides. Industrial Crops & Products 192: 116076.

THANIGAIVEL A et al. 2018. Development of an eco-friendly mosquitocidal agent from Alangium salvifolium against the dengue vector Aedes aegypti & its biosafety on the aquatic predator. Environmental Science & Pollution Research 25: 10340-10352.

THOMAS S. 2023. Is new dengue vaccine efficacy data a relief or cause for concern? Vaccines 8: 1-55.

VASANTHA SP et al. 2021. The efficacy of methanolic extract of Swietenia mahagoni Jacq. (Meliaceae) & a commercial insecticide against laboratory & field strains of Aedes aegypti (Linn.) & their impact on its predator Toxorhnchites splendens. Biocatalysis & Agricultural Biotechnology 31: 101915.

WALSH K. 2021. Bad Effects of Insecticide. Hunker. Available on: https://www.hunker.com/12003822/bad-effects-of-insecticide.

WHO. 2009. WORLD HEALTH ORGANIZATION. Dengue: guidelines for diagnosis, treatment, prevention & control. Paris: World Health Organization.

WHO. 2019. WORLD HEALTH ORGANIZATION. Yellow Fever. Available on: https://www.who.int/news-room/fact-sheets/detail/yellow-fever.

WHO. 2022. WORLD HEALTH ORGANIZATION. Zika Virus. Available on: https://www.who.int/news-room/fact-sheets/detail/zika-virus.

WHO. 2023. WORLD HEALTH ORGANIZATION. Expansión geográfica de los casos de dengue y Chikungunya más allá de las áreas históricas de transmisión en la Región de las Américas. Available on: https://www.who.int/es/emergencies/emergency-events/item/2023-DON448.

Downloads

Publicado

2024-09-13

Como Citar

CUERVO, Oscar Hernando Pardo; MARTÍNEZ, Laura Valentina Barrera; CAMACHO, Ingrid Dayana Jiménez; GORDON, Andrea Camila Martínez; LÓPEZ, Edwin Alejandro Figueredo; GUERRERO, Nidya Alexandra Segura. Extratos naturais como alternativa sustentável para o controle do Aedes aegypti: uma revisão atualizada. Revista de Ciências Agroveterinárias, Lages, v. 23, n. 2, p. 334–345, 2024. DOI: 10.5965/223811712322024334. Disponível em: https://periodicos.udesc.br/index.php/agroveterinaria/article/view/24515. Acesso em: 21 nov. 2024.

Edição

Seção

Artigo de Revisão - Ciência de Animais e Produtos Derivados